Gene Therapy Recurrent For Ovarian Cancer

Gene Therapy Recurrent For Ovarian Cancer

Recurrent ovarian cancer refers to cancer that has progressed or come back some time after you were first treated. Ovarian cancer is the most deadly disease of female reproductive system. Despite treatment, however, ovarian cancer sometimes recurs.

It may reappear somewhere in the abdomen or in distant sites. Conventional treatment options for recurrent ovarian cancer include surgery or chemotherapy or combination of both. However, long term survival rate of patients with recurrent ovarian cancer remains low.

Research continues to evaluate novel ways to treat this disease. Scientists are beginning a phase II clinical trial at the university of Kentucky medical center, Lexington to assess the effect of gene therapy on recurrent ovarian cancer. The clinical trial will evaluate the effectiveness of the p53 gene (p53 gene is a tumor suppressor gene) inserted into an adenovirus or common cold virus in combination with chemotherapy and standard surgical process to treat recurrent ovarian cancer.

Dr. Holly Gallion, M.D., professor, Department of Obstetrics and Gynecology, UK College of Medicine, and principal investigator of clinical trial said that gene therapy is an innovative approach to treat recurrent ovarian cancer as well as several other types of cancer. Dr. Gallion further said that that gene therapy will prove to be another effective instrument to fight recurrent ovarian cancer, along with surgery and chemotherapy.

Many diseases, including recurrent ovarian cancer develops due to faulty or mutated genes in cells. The objective of gene therapy is to deliver a correct replicate of the mutated gene directly into the nucleus of effected cells, thereby restoring normal function of the gene. To infix the engineered gene into the nucleus, the gene is enclosed in liposomes, a tiny vesicle made of molecules that resembles a cell membranes, or viruses. The adenovirus (DNA virus that cause upper respiratory tract infection), or common cold virus, often is used as gene delivery vector in gene therapy.

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Gene Therapy Recurrent For Ovarian Cancer