Apart from this, Gleevec is also effective on a number of other malignancies including gastrointestinal stromal tumors
Gleevec or Imatinib mesylate belongs to a separate class of drugs that specifically inhibit the enzyme activity of a number of tyrosine kinases. Recent research data on Gleevec indicates that Gleevec may be a promising treatment for other autoimmune diseases including Rheumatoid arthritis and Scleroderma. Scleroderma can be defined as a rare autoimmune connective tissue disorder characterized by hardening and tightening of skin and its underlying connective tissues, progressive visceral fibrosis, early skin lesions and vascular pathology. Scleroderma primarily results due to excessive deposition of collagen protein in the blood vessels connected to the skin. Scleroderma is a hereditary disorder that occurs more frequently in women than in men.
Experiments of Gleevec indicate that the drug has potent anti-fibrotic effects without any significant side effects. Studies on Scleroderma indicate that the disease progresses due to a stimulating effect of two important cytokines namely transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF). Both these cytokines cause an increase in the synthesis of extracellular matrix (ECM) proteins. Gleevec or Imatinib mesylate causes selective inhibition of TGF-β and PDGF signaling pathways. Experimental studies conducted on Scleroderma patients suggests that Gleevec or Imatinib mesylate strongly reduce the synthesis of myofibroblasts and restore the normal condition of the skin.
|• Accutane||• Arsenic||• Asbestos||• Duragesic Patch|
|• Effexor||• Evista||• Fosamax||• Gleevec|
|• Lead Poisoning||• Lexapro||• Medtronics||• Ortho Evra|
|• Paxil||• Prozac||• Risperdal||• Seroquel|
|• Zoloft||• Zyprexa|