Negative Effects Of Glutamine In Cancer

Negative Effects Of Glutamine In Cancer

The use of glutamine in cancer treatment has been researched in animals and humans, but the results often have been contradicting.

It has been seen that most people with cancer have abnormally low levels of glutamine Researchers became concerned about an increase in tumor growth with glutamine supplementation in patients with cancer after studies revealed an increase in cellular growth with glutamine supplementation.

Tumor progression was associated with an avid consumption of glutamine by tumor cells and a reduction in the activity of natural killer cells due to a decrease in glutathione concentrations in these cells. However, subsequent in vivo studies showed the opposite effect of a reduction in tumor growth. This was attributed to glutamine consumption by tumors being almost absolutely dissipative, and the researchers believed that an increase in the growth rate of the tumor due to this process should not be expected. It is believed that a tumor becomes a glutamine trap and worsens glutamine loss in patients with cancer and that glutamine has the potential to stall or halt tumor growth because of its immunomodulatory action

For this reason, some experts speculate that glutamine may prove to be a good addition to conventional treatment of cancer under certain conditions. In fact, nutritional support with glutamine supplements is often used in malnourished cancer patients undergoing chemotherapy or radiation treatments.

It is unknown whether taking glutamine may actually be harmful rather than beneficial in some or all cancer patients. Therefore, more research is needed to know whether use of glutamine is safe or effective to use as part of the treatment regimen for cancer.

More Articles :

Negative Effects Of Glutamine In Cancer